Meta- and Pooled Analyses Tumor Necrosis Factor (TNF) and Lymphotoxin-a (LTA) Polymorphisms and Risk of Non-Hodgkin Lymphoma in the InterLymph Consortium
نویسندگان
چکیده
Christine F. Skibola*, Paige M. Bracci, Alexandra Nieters, Angela Brooks-Wilson, Silvia de Sanjosé, Ann Maree Hughes, James R. Cerhan, Danica R. Skibola, Mark Purdue, Eleanor Kane, Qing Lan, Lenka Foretova, Maryjean Schenk, John J. Spinelli, Susan L. Slager, Anneclaire J. De Roos, Martyn T. Smith, Eve Roman, Wendy Cozen, Paolo Boffetta, Anne Kricker, Tongzhang Zheng, Tracy Lightfoot, Pierluigi Cocco, Yolanda Benavente, Yawei Zhang, Patricia Hartge, Martha S. Linet, Nikolaus Becker, Paul Brennan, Luoping Zhang, Bruce Armstrong, Alex Smith, Renee Shiao, Anne J. Novak, Marc Maynadie, Stephen J. Chanock, Anthony Staines, Theodore R. Holford, Elizabeth A. Holly, Nathaniel Rothman, and Sophia S. Wang
منابع مشابه
Genetic Variations of Tumor Necrosis Factor –α-308 and Lymphtoxin-α+252 in Non-Hodgkin Lymphoma and Acute Lymphoblastic Leukemia Patients
Objective(s): Non- Hodgkin lymphoma (NHL) and acute lymphoblastic leukemia (ALL) are two main hematological malignances which have been driven from lymphoid tissue. Genetic polymorphisms in tumor necrosis factor-α (TNF-α) -308 and lymphotoxin-α (LT-α) +252 may affect their transcription and expression which leads to their high plasma level. The frequency of the TNF-α (-308) and LT-...
متن کاملGenetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium.
BACKGROUND Common genetic variants in immune and inflammatory response genes can affect the risk of developing non-Hodgkin lymphoma. We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph). METHODS We selected 12 single-nucleotide polymorphisms for analysis,...
متن کاملGenetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.
Non-Hodgkin's lymphoma (NHL) is a cancer closely associated with immune function, and the tumor necrosis factor (TNF) G-308A promoter polymorphism, which influences immune function and regulation, was recently reported by the InterLymph Consortium to be associated with NHL risk. TNF signaling activates the nuclear factor-kappaB (NF-kappaB) canonical pathway, leading to transcriptional activatio...
متن کاملAssociation of Tumor Necrosis Factor-α (TNF-α) -308G>A and -238G>A Polymorphisms with Recurrent Pregnancy Loss Risk: A Meta-Analysis
Background: Studies have been carried out to evaluate the association of tumor necrosis factor-α (TNF-α) gene promoter region polymorphisms with recurrent pregnancy loss (RPL) risk. However, the results remain controversial and incomplete. Hence, we performed a meta-analysis to evaluate the association of TNF-α -308G>A and -238G>A polymorphisms with RPL risk. Materials and Methods: A comprehens...
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Multiple sclerosis (MS) is a complex polygenic disease in which gene-environment interactions are important. A number of studies have investigated the association between tumor necrosis factor-α (TNF-α) -308 G/A polymorphism (substitution G→A, designated as TNF1 and TNF2) and MS susceptibility in different populations, but the results of individual studies have been inconsistent. Therefore, per...
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تاریخ انتشار 2010